• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2023 Fiscal Year Annual Research Report

Clarification of Anesthesia Pharmacology Network by Brain Activity MRI

Research Project

Project/Area Number 20H03630
Research InstitutionJikei University School of Medicine

Principal Investigator

畑 純一  東京慈恵会医科大学, 医学部, 講師 (00568868)

Co-Investigator(Kenkyū-buntansha) 宮部 貴子  京都大学, ヒト行動進化研究センター, 助教 (10437288)
Project Period (FY) 2020-04-01 – 2024-03-31
Keywords安静時脳機能MRI / 超高磁場MRI / 麻酔 / コモンマーモセット / パルスシーケンス / 脳機能ネットワーク / グラフ理論 / 意識
Outline of Annual Research Achievements

麻酔・鎮静薬はこの意識を強制的に奪う。これまで多彩な麻酔・鎮静薬が開発され、細胞レベルでの作用機序は明らかにされているが、未だいかにして「無意識」を創出するのか詳細は不明である。この理由として脳内ネットワークに対する作用が未解明であることが挙げられる。これに対し本研究では脳機能イメージングとして脳活動の状況を計測することが可能である安静時脳機能MRI法(resting state - functional Magnetic Resonance Imaging; rs-fMRI) 法を用いることで、作用機序の異なる麻酔・鎮静薬による脳領域間の活動ネットワークを全脳領域間にて解析し、いかにして「無意識」を創出するのかを解明する。またヒトでは使用可能な薬剤に限りがあるため、薬物動態や脳機能がヒトと類似している非ヒト霊長類コモンマーモセットを対象とすることで解明を目指す。
当研究課題では、(1)超高磁場MRIによるrsfMRI実験、(2)麻酔薬を用いた実験、(3) ネットワーク解析の3段構成で研究を進めることで麻酔薬の影響を見出していく。これまで(1) 超高磁場MRIによるrsfMRI実験として、超高磁場MRIによる研究環境を当施設に実装完了と多チャンネルコイルの開発を達成した。また、(2)麻酔薬を用いた実験として、動物処置や頭蓋骨の手術手技を確立させた。(3)開発した覚醒下での実験環境に合わせてコモンマーモセットの脳活動計測を試み、得られた実験データと解析環境を用いて麻酔薬理に関する、脳活動自体の変化を評価し、その知見をまとめることで、麻酔による脳活動の知見を公開した。本年度(最終年度)は、ネットワーク解析の導入、そして実験個体数の増加を試み、安静時と麻酔下での脳活動をネットワークレベルで比較検証し、まとめあげ本課題の目的を達成した。

Research Progress Status

令和5年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和5年度が最終年度であるため、記入しない。

  • Research Products

    (25 results)

All 2024 2023

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (20 results) (of which Int'l Joint Research: 9 results)

  • [Journal Article] Identification of the reporter gene combination that shows high contrast for cellular level MRI2024

    • Author(s)
      Hayashi Naoya、Hata Junichi、Yoshida Tetsu、Yoshimaru Daisuke、Haga Yawara、Oshiro Hinako、Oku Ayano、Kishi Noriyuki、Shirakawa Takako、Okano Hideyuki
    • Journal Title

      PLOS ONE

      Volume: 19 Pages: -

    • DOI

      10.1371/journal.pone.0297273

    • Peer Reviewed / Open Access
  • [Journal Article] Restricted diffusion characteristics in oscillating gradient spin echo with mesoscopic phantom2024

    • Author(s)
      Oshiro Hinako、Hata Junichi、Nakashima Daisuke、Oshiro Rintaro、Hayashi Naoya、Haga Yawara、Hagiya Kei、Yoshimaru Daisuke、Okano Hideyuki
    • Journal Title

      Heliyon

      Volume: 10 Pages: e26391~e26391

    • DOI

      10.1016/j.heliyon.2024.e26391

    • Peer Reviewed / Open Access
  • [Journal Article] Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range2023

    • Author(s)
      Hata Junichi、Nakae Ken、Tsukada Hiromichi、Woodward Alexander、et al.
    • Journal Title

      Scientific Data

      Volume: 10 Pages: 1-8

    • DOI

      10.1038/s41597-023-02121-2

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Japan Monkey Centre Primates Brain Imaging Repository of high-resolution postmortem magnetic resonance imaging: The second phase of the archive of digital records2023

    • Author(s)
      Sakai Tomoko、Hata Junichi、Shintaku Yuta、Ohta Hiroki、Sogabe Kazumi、Mori Susumu、Miyabe-Nishiwaki Takako、Okano Hirotaka James、Hamada Yuzuru、Hirabayashi Toshiyuki、Minamimoto Takafumi、Sadato Norihiro、Okano Hideyuki、Oishi Kenichi
    • Journal Title

      NeuroImage

      Volume: 273 Pages: 120096~120096

    • DOI

      10.1016/j.neuroimage.2023.120096

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Group Surrogate Data Generating Models and similarity quantification of multivariate time-series: A resting-state fMRI study2023

    • Author(s)
      Okuno Takuto、Hata Junichi、Haga Yawara、Muta Kanako、Tsukada Hiromichi、Nakae Ken、Okano Hideyuki、Woodward Alexander
    • Journal Title

      NeuroImage

      Volume: 279 Pages: 120329~120329

    • DOI

      10.1016/j.neuroimage.2023.120329

    • Peer Reviewed / Open Access
  • [Presentation] Evaluation Of The Effect Of Microbiota On Brain Neural Fiber Bundles In Germ-Free Common Marmosets By Structural Connectome Analysis2023

    • Author(s)
      Chika Tokisugi, Fumiko Seki, Yuji Komaki, Takashi Inoue, and Junichi Hata
    • Organizer
      ISMRM & ISMRT Annual Meeting & Exhibition 2023
    • Int'l Joint Research
  • [Presentation] Diffusion Time Spectrum Analysis Observation Of Aquaporin Functional Dynamics2023

    • Author(s)
      Ayano Oku, Junichi Hata, Naoya Hayashi, Hinako Oshiro, Kanako Muta, Yawara Haga, Taeko Ito, Ryousuke Nakajima, Noriyuki Kishi, and Hideyuki Okano
    • Organizer
      ISMRM & ISMRT Annual Meeting & Exhibition 2023
    • Int'l Joint Research
  • [Presentation] Heterogeneous Regional Growth Process And Speed In Marmoset Brain: Multi-Modal Longitudinal MRI Study2023

    • Author(s)
      Akiko Uematsu, Makoto Fukushima, Junich Hata, Ayako Murayama, Noriyuki Kishi, Takuya Hayashi, and Hideyuki Okano
    • Organizer
      ISMRM & ISMRT Annual Meeting & Exhibition 2023
    • Int'l Joint Research
  • [Presentation] Developmental changes in brain activity in Scn1a knockout rats2023

    • Author(s)
      Norimichi Higurashi, Mayu Tahara, Junichi Hata, Masako Nishikawa, Ken Ito, Shinichi Hirose, and Hirotaka J Okano
    • Organizer
      The 16th Asian Oceanian Congress of Child Neurology Conference 2023
    • Int'l Joint Research
  • [Presentation] The Role of 31P-Magnetic Resonance Spectroscopy in Diagnosing and Monitoring the Acute Compartment Syndrome in rat models2023

    • Author(s)
      Ton That Nam Anh, Hiroki Ohta, Junichi Hata, James Okano Hirotaka,Takako Shirakawa
    • Organizer
      International Society of Magnetic Resonance in Medicine Japanese Chapter 8st Annual Scientific Meeting
    • Int'l Joint Research
  • [Presentation] Glimpse of the Hydrocephalic Brain: Impact of Awake Resting-State Functional Connectivity2023

    • Author(s)
      S. P. C. Wathsala, Junichi Hata, Ken Ito, Daisuke Yoshimaru, Hirotaka James Okano
    • Organizer
      International Society of Magnetic Resonance in Medicine Japanese Chapter 8st Annual Scientific Meeting
    • Int'l Joint Research
  • [Presentation] Myelin Abnormalities in Normal-Appearing White Matter Depicted by q-Space Diffusional MRI Correlate with Clinical Disabilities in Multiple Sclerosis2023

    • Author(s)
      Haruhiko Motegi, Satoshi Kitagawa, Kenji Kufukihara, Koji Sekiguchi, Junichi Hata, Hirokazu Fujiwara, Masahiro Jinzaki, Hideyuki Okano, Masaya Nakamura, Yasuyuki Iguchi, Jin Nakahara
    • Organizer
      The 9th Joint ECTRIMS-ACTRIMS Meeting
    • Int'l Joint Research
  • [Presentation] Assessment of neurodegenerative progression using quantitative T2 map in the SOD1G93A mouse model2023

    • Author(s)
      Momoka Kuramochi, Yuji Komaki, Hiroyuki Kameda, Kosuke Kudo, Junichi Hata
    • Organizer
      European Society for Magnetic Resonance in Medicine and Biology 2023
    • Int'l Joint Research
  • [Presentation] Mapping axonal projections of the marmoset prefrontal cortex2023

    • Author(s)
      Akiya Watakabe, Henrik Skibbe, Ken Nakae, Hiroshi Abe, Noritaka Ichinohe, Muhammad Febrian Rachmadi, Masafumi Takaji, Hiroaki Mizukami, Alexander Woodward, Rui Gong, Junichi Hata, David C. Van Essen, Hideyuki Okano, Shin Ishii, Testsuo Yamamori
    • Organizer
      Society for Neuroscience 2023
    • Int'l Joint Research
  • [Presentation] Directional and non-directional seed-based connectivity analysis of resting-state fMRI voxels in human and marmoset2023

    • Author(s)
      Takuto Okuno, Junichi Hata, Hideyuki Okano, Alexander Woodward
    • Organizer
      第46回日本神経科学会
  • [Presentation] Mapping axonal projections of the marmoset prefrontal cortex2023

    • Author(s)
      Akiya Watakabe, Henrik Skibbe, Ken Nakae, Hiroshi Abe, Noritaka Ichinohe, Muhammad Febrian Rachmadi, Masafumi Takaji, Hiroaki Mizukami, Alexander Woodward, Rui Gong, Junichi Hata, David C. Van Essen, Hideyuki Okano, Shin Ishii, Tstsuo Yamamori
    • Organizer
      第46回日本神経科学会
  • [Presentation] Extract brain regions relevant for estimating the consciousness level in animals under general anesthesia using resting-state functional MRI.2023

    • Author(s)
      Kanako Muta, Junichi Hata, Yawara Haga, Daisuke Yoshimaru, Kei Hagiya, Takaaki Kaneko, Hirotaka James Okano, Hideyuki Okano
    • Organizer
      第51回日本磁気共鳴医学会大会
  • [Presentation] Evaluation of water molecule exchange dynamics in the brain of in vivo and ex vivo mice using by diffusion time-dependent MRI2023

    • Author(s)
      Ayane Ishida, Hinako Oshiro, Junichi Hata, Daisuke Yoshimaru, Hideyuki Okano
    • Organizer
      第51回日本磁気共鳴医学会大会
  • [Presentation] Evaluation of the Effect of Microbiota on the Cerebellum of Germ-Free Marmosets -Structural Analysis Using DWI and immunohistochemistry-2023

    • Author(s)
      Chika Tokisugi, Fumiko Seki, Takashi Inoue, Kenji Kawai, Misa Mochizuki, Yuji Komaki, Junichi Hata
    • Organizer
      第51回日本磁気共鳴医学会大会
  • [Presentation] Development of brain image analysis tools for various mammalian species to build brain science research2023

    • Author(s)
      Miyu Okazaki, Junichi Hata, Kanako Muta, Karen Kurokawa, Hinako Oshiro, Kie Yamamoto, Dai Nagakubo, Ryohei Nishimura
    • Organizer
      第51回日本磁気共鳴医学会大会
  • [Presentation] Usefulness of Cuprizone-Induced Demyelination Mouse Model as a rs-fMRI Model2023

    • Author(s)
      Chino Kawai, Junichi Hata, Karen Kurokawa, Daisuke Yoshimaru, James Hirotaka Okano
    • Organizer
      第51回日本磁気共鳴医学会大会
  • [Presentation] Brain Network Changes in Mouse Eating Disorders Induced by Intermittent Administration of High-Fat Diets2023

    • Author(s)
      Karen Kurokawa, Junichi Hata, Mitsuki Rikitake, Chino Kawai, Daisuke Yoshimaru, James Hirotaka Okano
    • Organizer
      第51回日本磁気共鳴医学会大会
  • [Presentation] Interindividual similarity of anesthesia-specific networks in fMRI2023

    • Author(s)
      Takuto Marusaki, Daisuke Yoshimaru, Junichi Hata, Naoya Hayashi, Hinako Oshiro, Kei Hagiya, Nozomi Kurihara, Hideyuki Okano, James Hirotaka Okano
    • Organizer
      第51回日本磁気共鳴医学会大会
  • [Presentation] Evaluation of Multi-Channel Coils for Common Marmoset High Precision Head MRI Measurements2023

    • Author(s)
      Michika Abe, Junichi Hata, Hinako Oshiro, Kei Hagiya, Daisuke Yoshimaru, Hideyuki Okano
    • Organizer
      第51回日本磁気共鳴医学会大会
  • [Presentation] Observation of AQP4 function in astroglia using td-dMRI2023

    • Author(s)
      Ayano Oku, Kanako Muta, Junichi Hata, Noriyuki Kishi, Ryousuke Nakajima, Taeko Ito, Naoya Hayashi, Hinako Oshiro, Hideyuki Okano
    • Organizer
      第51回日本磁気共鳴医学会大会

URL: 

Published: 2024-12-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi