2023 Fiscal Year Final Research Report

Development of Evaluation Methods for Oxidative Stress in Renal Disease and Proposal of Novel Therapeutic Strategies and Fundamental Concepts

Research Project

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Project/Area Number	20H03696
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 53040:Nephrology-related
Research Institution	University of Fukui
Principal Investigator	Iwano Masayuki 福井大学, 学術研究院医学系部門, 教授 (20275324)
Co-Investigator(Kenkyū-buntansha)	森俊雄奈良県立医科大学, 医学部, 研究員 (10115280) 清野泰福井大学, 高エネルギー医学研究センター, 教授 (50305603) 岡沢秀彦福井大学, 高エネルギー医学研究センター, 教授 (50360813) 糟野健司福井大学, 学術研究院医学系部門, 准教授 (60455243)
Project Period (FY)	2020-04-01 – 2024-03-31
Keywords	酸化ストレス / FSP1 / チオレドキシン / ポドサイト / 尿細管障害 / PET/MRI
Outline of Final Research Achievements	Oxidative stress is known to be involved in the development of renal disease, but there are no antioxidants that have been clinically applied as therapeutic agents. In order to develop antioxidant drugs, a method to evaluate in vivo oxidative stress is necessary. In this study, we established a method to visualize and quantify in vivo oxidative stress in real time using our　originally developed oxidative stress imaging technology and biomarker technology. We also clarified the details of the mechanism by which secreted FSP1, an antioxidant we discovered, suppresses tubular damage. Furthermore, we demonstrated in vivo that FSP1 secreted by podocytes reduces tubular damage, thereby clarifying the existence of a podocyte-tubule linkage. This research is directly related to reducing the number of patients with end-stage renal failure through the clinical application of antioxidant drugs.
Free Research Field	腎臓内科学
Academic Significance and Societal Importance of the Research Achievements	本研究は、抗酸化薬の臨床応用により末期腎不全患者数を減少させることに直結する。独自開発した酸化ストレス・イメージング技術とバイオマーカー技術を臨床応用することで、抗酸化薬の適応疾患や適応病期の明確化や新たな抗酸化薬の開発が可能となる。さらに、腎疾患のみならず、酸化ストレスが関与する老化、発癌、動脈硬化や糖尿病の進展機序解明や治療法開発にも応用できる可能性もあり、本研究は健康寿命の延伸にもつながる可能性がある。