2022 Fiscal Year Final Research Report

Genetic assessments to detect patients requiring prophylactic total pancreatectomy for the prevention of pancreatic cancer.

Research Project

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Project/Area Number	20H03753
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 55020:Digestive surgery-related
Research Institution	Kagoshima University
Principal Investigator	Ohtsuka Takao 鹿児島大学, 医歯学域医学系, 教授 (20372766)
Co-Investigator(Kenkyū-buntansha)	谷本昭英鹿児島大学, 医歯学域医学系, 教授 (10217151) 山口浩埼玉医科大学, 医学部, 准教授 (20510697) 三森功士九州大学, 大学病院, 教授 (50322748) 東美智代鹿児島大学, 医歯学域鹿児島大学病院, 准教授 (60315405) 蔵原弘鹿児島大学, 医歯学域医学系, 助教 (70464469) 又木雄弘鹿児島大学, 鹿児島大学病院, 特任講師 (10444902) 井手野昇九州大学, 医学研究院, 助教 (90883421)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	膵癌 / 発癌 / 早期診断 / ゲノム / 予防 / クローン拡大
Outline of Final Research Achievements	Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas was known as high risk for the development of pancreatic ductal adenocarcinoma (PDAC). The aims of this study were to detect the genetic characteristics of IPMN having concomitant PDAC to apply this characteristic for the prevention of PDAC. Genetic alterations were comprehensively assessed using resected specimens of IPMNs of the pancreas and concomitant cPDAC, and presence of mutation of KLF4 is the good candidate as the marker for the possible development of cPDAC. To clarify the detailed mechanism of the development of PDAC in the pancreas with IPMN via KLF4 mutation and application of this specific marker to cancer prevention are the future challenges. Proteomics assessment is also conducted to support the genetic modification in cancer progression. In addition, microbiota assessment as the source of chronic inflammation demonstrated that several specific microbiome are involved in the progression of IPMN.
Free Research Field	消化器外科関連
Academic Significance and Societal Importance of the Research Achievements	依然、予後不良な膵癌の生存率向上のためには発症予防対策、早期診断法開発、新規治療法開発を行っていかなければならないが、本研究はその中で発症予防を目指したものである。膵癌発症高危険群として膵管内乳頭粘液性腫瘍(IPMN)に注目し、膵癌発症を予想できるマーカーを同定できたことは、膵癌発症の機序解明と膵癌発症前治療の開発へ発展していく可能性を秘めた学術的意義を持つばかりでなく、広く国民の健康増進につながる社会的意義を有する。