2022 Fiscal Year Final Research Report

Comprehensive study on clinical problems for percutaneous cardiopulmonary support system

Research Project

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Project/Area Number	20H03786
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 55060:Emergency medicine-related
Research Institution	National Cardiovascular Center Research Institute
Principal Investigator	Tatsumi Eisuke 国立研究開発法人国立循環器病研究センター, 研究所, 客員部長 (00216996)
Co-Investigator(Kenkyū-buntansha)	西中知博国立研究開発法人国立循環器病研究センター, 研究所, 部長 (00256570) 水野敏秀国立研究開発法人国立循環器病研究センター, 研究所, 室長 (40426515) 福嶌教偉国立研究開発法人国立循環器病研究センター, 病院, 部長 (30263247)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	経皮的心肺補助 / ECMO / 循環不全 / 呼吸不全 / 救急医療
Outline of Final Research Achievements	We performed research on the percutaneous cardiopulmonary support system. We conducted research of a pediatric ECMO system, which consisted of a membrane oxygenator, a centrifugal blood pump with a hydrodynamic bearing, and an antithrombotic coating. It was incorporated in a unit with an integrated drive device and monitoring system. The feasibility of　developing the pediatric ECMO system has been demonstrated by the evaluation of its antithrombogenicity, long-term durability, and the effect of a shunt circuit system between the oxygenator outlet and the pump inlet on the ECMO circuit blood flow and gas exchange capacity of an oxygenator under low bypass flow. The effect of the environmental condition for ECMO therapy in critical care and patient transportation situation on gas exchange capacity of an oxygenator was shown. The feasibility of percutaneous access system for the improvement of safety as well as circulatory and respiratory support capacity of ECMO system was demonstrated.
Free Research Field	人工臓器
Academic Significance and Societal Importance of the Research Achievements	経皮的心肺補助システムに関する臨床的課題解決を目指して、抗血栓性、長期耐久性等に優れた小児用小型ECMOシステム、院外救命救急現場や患者搬送下のECMOシステムによる治療、及びECMOシステムにおける安全性と循環呼吸補助能力を向上させるための経皮的アクセスシステムに関する研究を行った。これらは、経皮的心肺補助システムの臨床的課題解決に向けた研究として、重症循環呼吸不全患者における治療の発展に対して寄与することにより医療に貢献することが期待される。