2022 Fiscal Year Final Research Report

Elucidation of pathogenesis of endometriosis and endometriosis-associated ovarian cancer based on genomic analyses for normal endometrium

Research Project

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Project/Area Number	20H03821
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 56040:Obstetrics and gynecology-related
Research Institution	Niigata University
Principal Investigator	ENOMOTO Takayuki 新潟大学, 医歯学系, 特任教授 (90283754)
Co-Investigator(Kenkyū-buntansha)	井ノ上逸朗国立遺伝学研究所, ゲノム・進化研究系, 教授 (00192500) 吉原弘祐新潟大学, 医歯学系, 教授 (40547535) 安達聡介新潟大学, 医歯学総合病院, 助教 (50613147) 田村亮新潟大学, 医歯学総合病院, 助教 (70650620) 石黒竜也新潟大学, 医歯学総合病院, 助教 (80625690)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	正常子宮内膜 / 子宮内膜症 / 内膜症関連卵巣癌 / ゲノム / 癌関連遺伝子
Outline of Final Research Achievements	Genomic analysis of normal endometrium was performed at a wide range of ages. Genomic aberrations in normal endometrium were positively correlated with age and cumulative number of menstrual cycles. Genomic analysis of normal endometrium also revealed that endometrial glands with cancer-associated genetic mutations showed an advantageous spread in the endometrium. Furthermore, combination of 3D structural analysis of the endometrium with genomic analysis uncovered that each gland arising from the endometrial rhizome structure was monoclonal and shared the same genomic alterations, indicating that the rhizome structure plays an important role in shaping the spatial spread of cancer-associated genes in the endometrium.
Free Research Field	婦人科腫瘍
Academic Significance and Societal Importance of the Research Achievements	現代女性の月経回数は100年前に比べて９倍以上増加しており、子宮内膜が受けるストレスが増大している。そのため、子宮内膜関連疾患が増加傾向にあり、女性のQOLを低下させてしまう。本研究では、子宮内膜関連疾患の発症を予防する方法を検討する上で非常に重要な知見であり、新規予防法あるいは早期発見法を開発することで社会に還元していくことが可能である。