Analysis of neural network regarding oral function

2023 Fiscal Year Final Research Report

• Project/Area Number: 20H03887
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Osaka University
• Principal Investigator: Kogo Mikihiko 大阪大学, 大学院歯学研究科, 名誉教授 (20205371)
• Co-Investigator(Kenkyū-buntansha): 田中 晋 大阪大学, 大学院歯学研究科, 教授 (00367541) ; 山西 整 大阪大学, 大学院歯学研究科, 招へい教員 (20397780)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 咀嚼 / 口腔 / 嚥下

Outline of Final Research Achievements

On the olfactory side, OSM odors, which are known to have a mild sedative effect, were accompanied by a slowdown in chewing movements, which was shown to reduce appetite, food intake, and body weight.
In the masticatory motor system, it was suggested that the nucleus raphe obscures located at the rostral level of the sliced specimen may control respiratory activity, and the nucleus raphe obscures at the caudal level of the specimen may control the expression of swallowing activity. In addition, nucleus raphe obscures may regulate swallowing activity via 5-HT1A receptors in sliced specimens.
As a masticatory disintegration system, no rhythmic activity (chewing-like movements) from the trigeminal motor root was recorded in ALS mice. The chewing movement-like rhythm that was supposed to be transmitted to the trigeminal motor nucleus had been disrupted in the previous stage, the premotoneuron stage.

Free Research Field

口腔外科

Academic Significance and Societal Importance of the Research Achievements

口腔に関連する吸気や咀嚼・嚥下運動系の連携を実際に証明することができそのネットワークの一部を示せた意義は大きい。不確縫線核の口腔機能の役割の一部を示すことができた。Isolated BrainstemやALS系など新しい研究方法にアクセスしそれらが有用な方法であることを示せた。