2022 Fiscal Year Final Research Report

Elucidation of the molecular mechanism of epigenomic changes caused by intermittent hypoxia during pregnancy and construction of a foundation for medical applications

Research Project

PDF

Project/Area Number	20H03895
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 57070:Developmental dentistry-related
Research Institution	Tokyo Medical and Dental University
Principal Investigator	Ono Takashi 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30221857)
Co-Investigator(Kenkyū-buntansha)	細道純東京医科歯科大学, 大学院医歯学総合研究科, 講師 (00420258) 宮崎泰成東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30396999) 宮坂尚幸東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70313252) 財津崇東京医科歯科大学, 大学院医歯学総合研究科, 助教 (80611508) 下澤達雄国際医療福祉大学, 医学部, 主任教授 (90231365) 森丘千夏子東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座助教 (50796191) 滝敦子東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (20614481)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	閉塞性睡眠時無呼吸症 / 妊娠女性 / 胎児 / 出生児 / DOHAD仮説 / 間欠的低酸素
Outline of Final Research Achievements	Gestational intermittent hypoxia (IH) is a hallmark of obstructive sleep apnea that occurs frequently during pregnancy, and effects caused by this environmental change during pregnancy may be transmitted to the offspring. We aimed to clarify the effects of IH in both pregnant patients and rats on the growth and develeopment of infants and adolescent offspring rats. Clinical study suggested that higher BMI as a major risk factor for OSA among Japanese pregnant women. In addition, maternal OSA during pregnancy negatively influences birth weight and postnatal growth of the offspring. Animal model study suggest that respiratory and limb muscles are vulnerable to gestational IH, which induces altered energy metabolism with decreased aerobic motor function. These changes were partially owing to the decreased expression of adiponectin receptors and decreased capillary density in adolescent offspring rats.
Free Research Field	歯科矯正学
Academic Significance and Societal Importance of the Research Achievements	これまで認識されていなかった妊娠期の睡眠呼吸障害が、次世代に成長発育障害をもたらす分子基盤の解明を国内外にて初めて行うことにより、妊娠期OSAのスクリーニングの重要性を啓発し、先制医療基盤構築の契機となり、巨視的には医療費の削減と「すべての人に健康と福祉を」という持続可能な開発目標（SDGs）に沿った健康長寿社会を実現する波及効果が期待できる。