2023 Fiscal Year Final Research Report

Lifestyle and environmental factors associated with age at menarche and age at menopause that are risk determinants of several chronic diseases

Research Project

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Project/Area Number	20H03939
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research Institution	Gifu University
Principal Investigator	Nagata Chisato 岐阜大学, 大学院医学系研究科, 教授 (30283295)
Co-Investigator(Kenkyū-buntansha)	上山純名古屋大学, 医学系研究科(保健), 准教授 (00397465) 和田恵子岐阜大学, 大学院医学系研究科, 准教授 (00532673) 近藤高明名古屋大学, 医学系研究科(保健), 教授 (00195900)
Project Period (FY)	2020-04-01 – 2024-03-31
Keywords	初経 / 閉経 / がん / 循環器疾患
Outline of Final Research Achievements	The present study was aimed to identify the lifestyle and environmental factors associated with age at menarche and age at menopause that are risk determinants of several chronic diseases including cancer and cardiovascular diseases, among participants in the cohorts of children and adults. Our data suggested that blood estradiol and IGF-1 levels and dietary intakes of saturated fat, cholesterol, staples, and potatoes were associated with age at menarche. Urinary level of acrylamide metabolites was not associated with age at menarche. Sleep duration was associated with age at menopause. Urinary level of melatonin metabolite and passive smoking status were not associated with age at menopause. We developed the estimation of dietary intakes of melatonin, acrylamide, advanced glycation end products, and polyamines. However, none of these factors were associated with age at menopause.
Free Research Field	Epidemiology
Academic Significance and Societal Importance of the Research Achievements	初経、閉経年齢とも乳がん、卵巣がん、子宮体がん、心血管障害、うつ病という複数の疾患リスクに関わるが、その年齢時期が早いと、ある疾患のリスクを上げる一方、ある疾患のリスクを下げるという相反する関連性が知られている。このため、初経年齢、閉経年齢を規定する因子を同定することにより、複数の疾患影響を考慮した上での予防の在り方を目指すことが重要である。また、新規の規定要因を見出すため、特に新しい栄養因子の推定も可能としたことは、学術的な意義もある。