2023 Fiscal Year Final Research Report

Measurement of urinary and salivary cyclophosphamide of hospital staff and verification of guidelines for measures against exposure to anticancer drugs

Research Project

PDF

Project/Area Number	20H03969
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 58050:Fundamental of nursing-related
Research Institution	Nagoya University of Arts and Sciences (2021-2023) Ichinomiya Kenshin College (2020)
Principal Investigator	SHIRATORI SATSUKI 名古屋学芸大学, 看護学部, 教授 (20291859)
Co-Investigator(Kenkyū-buntansha)	大石ふみ子聖隷クリストファー大学, 看護学部, 教授 (10276876) 葉山有香同志社女子大学, 看護学部, 准教授 (30438238) 山幡朗子愛知医科大学, 看護学部, 准教授 (40440755) 鈴江智恵一宮研伸大学, 看護学部, 教授 (40807319) 出原弥和名古屋学芸大学, 看護学部, 准教授 (80320985) 伊藤眞由美金城学院大学, 看護学部, 准教授 (90241207)
Project Period (FY)	2020-04-01 – 2024-03-31
Keywords	抗がん薬 / シクロホスファミド / 病院職員 / 看護師 / 抗がん薬曝露対策 / リスク認識 / 労働安全
Outline of Final Research Achievements	The purpose of this research is to (1) clarify the content of cyclophosphamide (CPA) in the saliva and urine of hospital staff working in wards and outpatient departments handling anticancer drugs by quantitatively measuring it, and (2) clarify guidelines for these occupations. The purpose of this study was to clarify the actual and perceived compliance with the rules and to clarify the differences in protective behavior between occupations. We obtained cooperation from 62 people at 8 facilities with outpatient cancer chemotherapy rooms and investigated the CPA content in saliva and urine. As a result, CPA was not detected in the saliva samples, but CPA was detected in the urine of 6 people. By occupation, there were 4 nurses and 2 pharmacists. In order to clarify the relationship with exposure status, an environmental pollution survey was conducted at Facility A due to four types of anticancer drugs.
Free Research Field	基礎看護学　看護管理
Academic Significance and Societal Importance of the Research Achievements	医療従事者の抗がん薬曝露のリスクに対して漸く認識が高まってきたが、曝露対策は各施設によって異なり実態は十分に把握できていない。この背景には日本では法的規制がないことと抗がん薬曝露の生物学的調査が高額であることが要因の一つとなっている。本研究では、医師、薬剤師、看護師から事務職員までを対象として曝露状況を調査し、質問紙調査から被爆状況との関連を明らかにした。結果から直接危険薬を扱わない状況においても曝露していることが明らかになった。本調査による知見は危険薬曝露の根拠資料となり、医療従事者の労働安全に寄与する。