• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2023 Fiscal Year Final Research Report

Mechanistic insights into lactate-induced adaptation and potential applications

Research Project

  • PDF
Project/Area Number 20H04071
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionThe University of Tokyo

Principal Investigator

Hatta Hideo  東京大学, 大学院総合文化研究科, 教授 (60208535)

Co-Investigator(Kenkyū-buntansha) 北岡 祐  神奈川大学, 人間科学部, 教授 (30726914)
星野 太佑  電気通信大学, 大学院情報理工学研究科, 准教授 (70612117)
Project Period (FY) 2020-04-01 – 2024-03-31
Keywords乳酸
Outline of Final Research Achievements

This study revealed that lactate enhances mitochondrial respiratory function, and also examined the effects of sex differences in lactate metabolism and sex hormone deficiency. Besides showing that inhibition of lactate transporters reduced locomotor performance in mice, a method was established to calculate lactate production during exercise from blood lactate concentrations. Furthermore, interval exercise experiments with different rest periods showed that even with identical exercises, differences in metabolite concentrations, particularly lactate, may lead to different exercise benefits.

Free Research Field

運動生理生化学

Academic Significance and Societal Importance of the Research Achievements

疲労物質だと誤解されたきた乳酸が、運動パフォーマンスに関わるエネルギー基質であり、ミトコンドリアの質的な変化をもたらす物質であることを示したことの学術的な意義は大きいと考えられる。さらに、血中の乳酸濃度から筋での産生量を算出する方法を確立できたことで、乳酸測定を活かした効率的なトレーニングにつながる可能性を示すことができた。また、乳酸代謝の性差を明らかにすることができたことも社会的な意義に繋がる成果として挙げられる。

URL: 

Published: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi