2022 Fiscal Year Final Research Report
Nrf2, a transcription facor for anti-oxidative stress response, ameliorates sarcopenia in obese subjects.
Project/Area Number |
20H04119
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 59040:Nutrition science and health science-related
|
Research Institution | University of Tsukuba |
Principal Investigator |
Shoda Junichi 筑波大学, 医学医療系, 客員教授 (90241827)
|
Co-Investigator(Kenkyū-buntansha) |
鈴木 英雄 筑波大学, 医学医療系, 准教授 (00400672)
柳川 徹 筑波大学, 医学医療系, 教授 (10312852)
石井 亜紀子 筑波大学, 医学医療系, 講師 (10400681)
岡田 浩介 筑波大学, 医学医療系, 准教授 (80757526)
呉 世昶 筑波大学, 医学医療系, 研究員 (10789639)
|
Project Period (FY) |
2020-04-01 – 2023-03-31
|
Keywords | 肥満 / サルコペニア / Nrf2 / 臓器連関 / 非アルコール性脂肪性肝炎 / NASH |
Outline of Final Research Achievements |
Hyper-endotoxicemia associated with obesity induces an inflammatory and/or oxidative stress in skeletal muscles and thereby underlies the development of sarcopenia via gut-muscle axis or gut-liver-muscle axis. On the other hand, Nrf2 acts as an in vivo regulator for oxidative stress. In this study, the roles of Nrf2 in muscles were investigated with special reference to an inhibition of sarcopenia. In obese mice, Nrf2 contributed to inhibit the atrophic changes of slow muscle fibers and to preserve the mitochondrial function in muscles. Moreover, Nrf2-related muscle preservation also contributed to prevent steatohepatitis via gut-liver-muscle axis in the mice.
|
Free Research Field |
健康応用科学
|
Academic Significance and Societal Importance of the Research Achievements |
肥満にサルコペニアを随伴したサルコペニア肥満は生命予後が不良であり,その抑止は重要な医療課題である.本研究では,肥満者がサルコペニアに至るルートに着目し,Nrf2がサルコペニアの形成に対して防御的に機能することを明らかにした.本研究の結果は,肥満者における骨格筋劣化に対して,Nrf2を標的とした新たな予防・治療法を構築する基盤となる可能性があり,今後の発展が期待される.
|