Exploratory Research on Therapeutic Efficacy Enhancing Agents in Sono-dynamic Therapy

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H04555
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Okamoto Jun 東京女子医科大学, 医学部, 非常勤講師 (10409683)
• Co-Investigator(Kenkyū-buntansha): 吉澤 晋 東北大学, 工学研究科, 教授 (30455802) ; 村垣 善浩 東京女子医科大学, 医学部, 教授 (70210028)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 集束超音波 / HIFU

Outline of Final Research Achievements

To evaluate the basic performance of HIFU, precise measurement of the HIFU beam, temperature measurement of the HIFU focus, and HIFU irradiation experiments on the porcine pancreas were conducted. The temperature measurement of the HIFU focal point was performed by fabricating a jig to insert a thin thermocouple at a precise position in relation to the excised organ. In the irradiation experiment of the pig pancreas, the effects on the non-target area and the tissue observation of the target area were conducted.

Free Research Field

超音波治療

Academic Significance and Societal Importance of the Research Achievements

集束超音波治療に音響力学的効果を組み合わせた治療法は、腫瘍集積性のある音響感受性薬剤を併用することでHIFU照射出力を低減させつつ腫瘍破壊効果を増強させ、HIFU治療のリスクであった治療部位以外への意図しない照射による正常細胞への影響を低減させる可能性がある。