2023 Fiscal Year Final Research Report
Elucidating the physiological activities of food components using a Drosophila disease model
| Project/Area Number |
20K02376
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 08030:Family and consumer sciences, and culture and living-related
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| Research Institution | Yamanashi Gakuin Junior College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
今井 伸二郎 東京工科大学, 応用生物学部, 教授 (50629152)
小林 公子 静岡県立大学, 食品栄養科学部, 教授 (90215319)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 食情報 / ショウジョウバエ |
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| Outline of Final Research Achievements |
We analyzed the unknown physiological activity of food and its biological components using Drosophila melanogaster as an experimental animal.
We discovered that the fatty acid tryptamide contained in cacao may activate sirtuins, which inhibit aging and extend the lifespan of the individual. The study further demonstrated that the ingestion of carnitine, which is involved in fatty acid metabolism, may promote fat metabolism. Furthermore, as the physiological effects of carnitine intake may differ depending on the level of physical activity, we conducted human clinical trials to clarify its relationship with exercise habits. We established a new Drosophila CNDP mutant strain for the dipeptide-degrading enzyme CNDP and demonstrated that CNDP is involved in the oxidative stress response.
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| Free Research Field |
食科学
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| Academic Significance and Societal Importance of the Research Achievements |
食品成分のうち、人体にどのような生理活性作用を及ぼすのかわかっていない食品成分は多数存在する。それら食品成分の機能について、ショウジョウバエを用いて解析することよって、対象とする食品成分が多細胞生物に対して生理活性作用を持つのか、ヒトに対しても生理活性を有するのか、その生理活性は多細胞生物に普遍的な作用であるのかの知見を得ることができる。ショウジョウバエに対する生理活性が老化抑制機能や脂質代謝調節機能が示唆された場合、高等動物による実験や臨床試験を経て、ヒトにおける生活習慣病の発症予防や健康長寿維持への貢献に繋がる。
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