2022 Fiscal Year Final Research Report
Fabrication of cell-layered artificial tissue substitute and optimization of mechanical design
| Project/Area Number |
20K04169
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 18010:Mechanics of materials and materials-related
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| Research Institution | Kyushu Institute of Information Sciences |
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Principal Investigator |
Arahira Takaaki 九州情報大学, 経営情報学部, 准教授 (30706958)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | バイオプリンティング / 足場材 / 力学特性 / 骨芽細胞 / 骨再生 / Tissue engineering / コラーゲン / アルギン酸 |
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| Outline of Final Research Achievements |
The purpose of this study is to promote organization by cells and to construct uniform tissues. To solve this problem, bioprinting technology was used. Three-dimensional structures with bioink showed better mechanical properties than commercially available products. The bioink also showed superior cell differentiation ability. The bioink produced in this study promoted the proliferation and differentiation of osteoblasts, suggesting that the entire three-dimensional structure was organized efficiently.
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| Free Research Field |
生体工学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では，従来の細胞培養手法における播種した細胞が足場材で局所的に分布し，組織化を行うという問題点を解決するため，バイオプリンティング技術に着目し，足場材内での細胞の分布を均一化し，均一な組織を作製することを目的としている．そのためのバイオインクを作製し，実際に三次元構造体をバイオプリンタで作製し，力学特性やin vitro評価等を実施した．その結果，本研究で作製したバイオインクが市販品よりも力学特性や細胞の組織化で優れていることを明らかにした．
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