Fabrication of surfaces with high bone formation ability by alloying and compositing titanium with bone-containing elements

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K05130
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 26040:Structural materials and functional materials-related
• Research Institution: Nagoya University
• Principal Investigator: Hieda Junko 名古屋大学, 工学研究科, 准教授 (40566717)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: チタン合金 / 骨含有元素 / 非平衡合金 / 骨形成能

Outline of Final Research Achievements

In this study, we attempted to prepare Ti-Mg and Ti-Ca alloy films by alloying Ti with bone-containing elements such as Ca and Mg, to develop new medical Ti materials with better bone formation ability than conventional Ti and Ti alloys. We succeeded in controlling the composition of the alloy films and clarified the relationship between the Ca and Mg concentrations and the crystal structure, surface properties, and biocompatibility of the fabricated alloy films; the addition of Ca or Mg resulted in faster formation of hydroxyapatite in simulated body fluids compared to Ti.

Free Research Field

医療用金属材料

Academic Significance and Societal Importance of the Research Achievements

従来の溶解法では合金化できなかった元素が添加可能となったことにより、医療用金属材料の開発における添加元素の選択肢および可能性を広げることができる。さらに、本研究成果により、Ti合金製部材を体内に埋入してから骨との接着にかかる期間の改善が期待できる。