Characterization of functional self-assembled lipid molecular phase immobilized on macroporous polymer particles and its application to separation process

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K05198
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 27010:Transport phenomena and unit operations-related
• Research Institution: University of Miyazaki
• Principal Investigator: Shiomori Koichiro 宮崎大学, 工学部, 教授 (80235506)
• Co-Investigator(Kenkyū-buntansha): 松根 英樹 宮崎大学, 工学部, 准教授 (10380586)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: クライオゲル / 多孔性ポリマー微粒子 / 含浸担持 / 抽出剤 / リン脂質膜 / キラル認識 / 銅抽出 / 蛍光プローブ

Outline of Final Research Achievements

Hydrophobic cryogels were prepared by polymerization in a frozen state using the hydrophobic monomer, Trim, and organic solvents. When acetic acid and DMSO were used as organic solvents, super-macroporous cryogels were formed. The hydrophobic cryogels were impregnated with LIX84-I, an extractant for Cu(II); LIX84-I was impregnated in the hydrophobic cryogels and was able to extract Cu(II). The pore distribution was determined and the adsorption properties of the impregnated extractant for Cu(II) were elucidated.
Phospholipid membranes immobilized on porous polymeric microparticles formed a bilayer structure similar to liposomes; adsorption of L- and D-types tryptophan was performed, with selective adsorption of only L-tryptophan and chiral recognition adsorption of only L-body from mixed solutions of L- and D-tryptophans.

Free Research Field

反応分離工学

Academic Significance and Societal Importance of the Research Achievements

多孔質ポリマー微粒子に固定化したリン脂質膜がキラル認識能を発現した例は少なく、本研究により、固体表面上にリポソームに類似したリン脂質膜構造を形成し、キラル認識を行うことが示された．固体表面の修飾方法および表面の機能化で意義は大きい。
疎水性モノマーと有機溶媒を用いた疎水性クライオゲルを調製した。抽出剤のLIX84-Iを添加してゲルに内包して銅の吸着に応用出来ることを初めて示した．モノマー濃度、有機溶媒、および凍結温度が細孔特性におよぼす影響を明らかにした。疎水性の抽出剤は疎水性クライオゲルに内包され繰り返し抽出に使用出来た。これらの超多孔質材料を用いた新しい分離プロセスの構築が可能となる。