2022 Fiscal Year Final Research Report
Numerical and experimental examinations for electron-linear-accelerator-driven neutron source for boron neutron capture therapy
| Project/Area Number |
20K05378
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 31010:Nuclear engineering-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
hiraga fujio 北海道大学, 工学研究院, 助教 (00228777)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | ホウ素中性子捕捉療法 / 加速器中性子源 / 電子線形加速器 / 光中性子 / ビーム成形装置 / 腫瘍組織と正常組織のRBE線量率 / 中性子ビームの照射時間 |
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| Outline of Final Research Achievements |
We examined the feasibility of an electron LINAC based beam shaping assembly (BSA) with a tungsten target. Computer simulations were carried out for the design and construction of a BSA that is driven by a 15-kW beam of 33-MeV electrons. We calculated the tumor and normal-tissue RBE dose rate in a phantom exposed to the beam of the BSA, when the 10B density in tumor and normal-tissue was 65 and 0.65 ppm, respectively. With a limit on the peak normal-tissue RBE dose of 10 Gy-eq, the advantage depth (AD) and the irradiation time of a beam (IT) were estimated at 8.7-cm and 2361 s, respectively. The neutron measurement experiment was carried out to demonstrate the performance of the beam of the BSA. The experimental results suggested that computer simulations provided a good estimate of the AD and IT values for the phantom that is irradiated by the beam of the BSA.
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| Free Research Field |
原子力学
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| Academic Significance and Societal Importance of the Research Achievements |
33-MeVの電子の15-kWのビームを生成するLINACは加速におけるビームロスが少なく、エネルギー効率が高い。そのため、高周波発生装置や電源装置を含めて加速器の建設や運転に関わるコストが低くなると考えられ、医療施設に導入するうえで大きな利点になると考えられる。本研究により、33-MeVの電子の15kWのビームにより駆動されるビーム成形装置を用い、新規ホウ素薬剤を利用する場合、ビームは許容できる照射時間のうちに大脳の中心付近に位置する腫瘍に治療効果のある線量を処方できることが分かった。加速器に基づくホウ素中性子捕捉療法の利用を促進するための、新たな有効な手段を示すことができたと考えられる。
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