Investigation of N-chiral Ligands for development of 3d transition metal catalysts

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K05493
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 33020:Synthetic organic chemistry-related
• Research Institution: Chuo University
• Principal Investigator: Iwamoto Takahiro 中央大学, 理工学部, 助教 (50735355)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 不斉配位子 / 3d遷移金属触媒 / P-キラル配位子

Outline of Final Research Achievements

Facile synthetic methods for novel P-chiral ligands have been established for development of chiral 3d transition metal catalysts. The newly-developed methods are scalable and allow for introduction of diverse donor sites into P-chiral backbons. Complexation studies using a palladium metal as a model demonstrated that some of the developed P-chiral ligands have unique functions such as ability to generate a N-chirogenic center induced by chiral induction from the inherent P-chirogenic center.

Free Research Field

有機合成化学、有機金属化学

Academic Significance and Societal Importance of the Research Achievements

元素戦略的観点から、従来の貴金属を代替する3d遷移金属触媒の開発が求められているが、医農薬品の創製に必要な不斉合成への展開は限定的である。本研究では、「3d遷移金属触媒専用配位子」とでも呼べる独自の配位子を設計し、それらの合成法を確立するとともに、モデル錯体を用いて配位子の特性の一部を明らかにした。本知見を基に有用3d遷移金属触媒の創製を行うことで、持続可能な有用物質供給基盤の構築に繋がると考えている。