Development of caged compounds controllable from outside the body

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K05752
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 37030:Chemical biology-related
• Research Institution: Nagoya City University
• Principal Investigator: Ieda Naoya 名古屋市立大学, 医薬学総合研究院(薬学), 講師 (00642026)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: ケージド化合物 / 一酸化窒素 / 可視光 / 低酸素 / 酸素スカベンジャー

Outline of Final Research Achievements

By using the red light-controlled NO donor we have developed, it was shown that red light irradiation can ameliorate the blood flow disturbance in a model rat of neurogenic erectile dysfunction. We also found that the NO release efficiency increased with changing the antenna moiety of the light-controlled NO donor to tellurium-containing rhodamine by several tens of times compared to conventional compounds, and confirmed that it could efficiently relax rat aortic strips.
In addition, for the purpose of photo-control of bioactive molecules other than NO, we developed a new blue light caged group triggered by photo-induced electron transfer and confirmed that the activity of bioactive molecules can be controlled by blue light.
As described above, we developed several bioactive molecules controllable by visible light and showed that they can be controlled in vivo.

Free Research Field

ケミカルバイオロジー

Academic Significance and Societal Importance of the Research Achievements

ラットの病態モデルにおいても、生体透過性の比較的高い赤色光を用いることで病態改善が確認ができたことから、近年注目されている光免疫療法のように、狙った部位に活性を集中させることのできる新たな光化学療法の基盤技術を構築できたと言える。今後は、薬剤分子の体内動態や毒性を精査、制御していくことで、光と小分子を用いた新たな治療法の候補として期待される。