2022 Fiscal Year Final Research Report
Development of carrier molecule targeted GLUT
| Project/Area Number |
20K05755
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 37030:Chemical biology-related
|
|---|
| Research Institution | Okayama University (2022)
Tokyo University of Science (2020-2021) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | ホウ素中性子線捕捉療法 / BSH / キャリア分子 |
|---|
| Outline of Final Research Achievements |
In this research, we developed a technology to deliver BSH, which is used as a BNCT drug, into cells. The original plan was to develop carrier molecules that induce GLUT-mediated uptake, but we found that nanoparticles could be formed by mixing BSH with cationic polymers. Therefore, we decided to focus on these nanoparticles. When the cytotoxicity and cell membrane permeability of this nanoparticle were evaluated, it was revealed that the membrane permeability was significantly improved compared to BSH alone.
|
| Free Research Field |
生物有機化学
|
| Academic Significance and Societal Importance of the Research Achievements |
BSHは構造中に複数のホウ素原子を有している事からBNCT用薬剤として有用であるにもかかわらず、その細胞膜透過性の低さからあまり使用されていない。本研究成果によってカチオン性ポリマーを混合するだけで、BSHの欠点である膜透過性を改善できたという点は今後のBNCT研究に大きく貢献するものである。
|
