Approach to prevention and improvement of chronic kidney disease-like vascular disorders caused by prostacyclin deficiency

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K05915
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Kanagawa Institute of Technology
• Principal Investigator: Yokoyama Chieko 神奈川工科大学, 健康医療科学部, 教授 (90200914)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: プロスタサイクリン / PGI2 / 腎障害 / 多価不飽和脂肪酸

Outline of Final Research Achievements

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), among other n-3 polyunsaturated fatty acids, have shown numerous clinical benefits in the treatment and prevention of lifestyle-related diseases, and are actively incorporated into dietary and nutritional therapies. However, the detailed mechanisms of their actions are not yet fully understood. Prostacyclin (PGI2), a physiologically active substance crucial for maintaining vascular homeostasis derived from arachidonic acid, a n-6 essential polyunsaturated fatty acid, plays an important role. On the other hand, it has been elucidated that through the IP receptor pathway, PGI2 is involved in promoting inflammation. This study investigates the effects of n-3 fatty acids on various tissue-cultured cells.

Free Research Field

病態生化学　栄養学　薬理学

Academic Significance and Societal Importance of the Research Achievements

n-3系多価不飽和脂肪酸の具体的な分子メカニズムや細胞レベルの作用機序を明らかにすることは、臨床的効果を裏付けるためにも重要である。n-3系不飽和脂肪酸が様々な組織培養細胞に与える影響が詳細に検討されつつあり、本研究においては、n-3系不飽和脂肪酸が脂肪細胞、肝細胞、腎尿細管細胞などの細胞レベルでどのようにして炎症反応を調節し、血管機能やその他の生理プロセスに影響を与えるかを理解するための重要な一歩であり、生活習慣病が引き起こす慢性腎臓病の予防や治療法開発に寄与すると考える。