Crystal structure of the C-terminal domain of envelope protein VP37 from white spot syndrome virus

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K06238
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 40040:Aquatic life science-related
• Research Institution: Osaka University
• Principal Investigator: Suzuki Mamoru 大阪大学, 蛋白質研究所, 准教授 (40280507)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: X線結晶学 / る甲殻 類急性ウイルス血症

Outline of Final Research Achievements

Research to determine the 3D structures of infection-associated molecules to elucidate the infection mechanism of crustacean acute viremia has just begun. In this study, we elucidated the X-ray crystal structure of VP37 and proposed a model of its complex with infection-associated VP28. We hope that the results of this study will be used in future studies to elucidate the mechanisms of WSSV infection and the important information base for the prevention and protection of crustacean acute viremia.

Free Research Field

X線結晶構造学

Academic Significance and Societal Importance of the Research Achievements

分解能2.51AでVP37のX線結晶構造解析に成功した。