2022 Fiscal Year Final Research Report
Cross-talk mechanism between muscle-derived irisin and bone-derived osteocalcin for robust skeletal construction in poultry.
| Project/Area Number |
20K06361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 42010:Animal production science-related
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | ニワトリ / 骨 / 筋 / イリシン / オステオカルシン / クロストーク機構 / 骨格構築 |
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| Outline of Final Research Achievements |
Poultry suffer significant economic losses due to frequent leg weakness and egg breakage caused by eggshell thinning. This is thought to be the result of the failure to construct a strong skeleton during growth. In this study, we elucidated and compared the crosstalk mechanism between bone and muscle in meat- and egg-type chick embryos and found that bone-derived osteocalcin regulates muscle formation, and muscle-derived FNDC5/irisin regulates bone formation. Based on the results of these studies, we expect that this research will lead to the prevention of leg weakness and egg breakage in poultry in future.
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| Free Research Field |
動物解剖生理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、家禽における骨（オステオカルシン）と筋（FNDC5/イリシン）のクロストーク機構を明らかにしたものである。本研究成果は、肉用鶏における脚弱ならびに卵用鶏における破卵の防止をもたらし、日本国民はもちろんこと世界中の人々へ安全・安心な畜産物の持続的な供給を可能とする。また、家禽の強健な骨格構築をもたらすことで動物福祉の向上に寄与する。さらには、本研究成果は、ヒトの加齢に伴う筋量減少症（サルコペニア）や骨粗しょう症の解明に貢献するものと考える。
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