2023 Fiscal Year Final Research Report
Relationship between structural symmetry and function of the torque-generating unit in bacterial flagellar motors
| Project/Area Number |
20K06564
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 43030:Functional biochemistry-related
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| Research Institution | Hosei University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | べん毛モーター / 回転計測 |
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| Outline of Final Research Achievements |
The bacterial flagellar motor is a reversible rotary nano-machine that rotates at high speed and runs with high efficiency. This study focused on the stator unit responsible for the chemical-mechanical energy conversion. We characterized the “hetero” stator unit by breaking its structural symmetry, the stator assembly depending on the load to the motor, the specificity of coupling ions on stator units, and newly developed fluorescent protein-fused stator units. The results obtained here are significant in that they will provide the basic technology for further analysis of the motor rotation.
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| Free Research Field |
生物物理学
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| Academic Significance and Societal Importance of the Research Achievements |
細菌べん毛モーターは，人工モーターでは実現できないような高効率，高速回転を実現するわずか直径50 nmの分子機械である．このモーターの回転機構が解明されれば，人工的な小型モーターの開発にも貢献できると期待される．本研究では，エネルギー変換の中心を担う固定子ユニットについて研究をおこない，今後の研究の基盤的な技術となる手法を構築できた．
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