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2022 Fiscal Year Final Research Report

Developing computational methods for quantitative analysis of 3D transcriptional domain

Research Project

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Project/Area Number 20K06606
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 43060:System genome science-related
Research InstitutionThe University of Tokyo

Principal Investigator

Park Sung-Joon  東京大学, 医科学研究所, 准教授 (40759411)

Project Period (FY) 2020-04-01 – 2023-03-31
Keywordsゲノム高次構造 / 遺伝子転写制御 / バイオインフォマティクス
Outline of Final Research Achievements

Genomic long-range contacts mediate the regulation of gene expression, which is essential for maintaining normal genome functions and for avoiding abnormal cell differentiation. The long-range contacts in the spatial vicinity of target genes provide the 3D space where a wide variety of transcriptional regulators are highly interacting with each other and contribute to forming the 3D transcriptional domain. In this study, we developed a computational model to comprehensively identify genomic and epigenetic regulators from the transcriptional domain and analyze the impact of regulators quantitatively. This has enabled a more in-depth analysis of the functional importance of the higher-order chromatin structures.

Free Research Field

バイオインフォマティクス

Academic Significance and Societal Importance of the Research Achievements

本研究では、ゲノムトポロジーと遺伝子発現の動的共役をより包括的に理解するための情報科学的手法を提案した。つまり、既存の発現制御に重要なコンタクトゲノム部位の同定に留まらず、プロモーターとコンタクトゲノム部位の配列情報から潜在的な転写因子間相互作用を推定し、さらに、コファクターやメディエーターのタンパク質間相互作用を取り入れ、転写ドメイン内の制御シグナルの伝達様相を可視化した。これは、いわば「ゲノム高次構造を介した転写制御シグナローム」という新しい学術的分野の展開に貢献するであろう。

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Published: 2024-01-30  

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