2023 Fiscal Year Final Research Report
Evaluation of molecular bases for signal transduction by "signaling endosomes"
| Project/Area Number |
20K06633
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 44010:Cell biology-related
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| Research Institution | Kitasato University (2022-2023)
Tohoku University (2020-2021) |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 増殖因子 / 受容体エンドサイトーシス / 細胞内小胞 / 解糖系 / 情報伝達 |
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| Outline of Final Research Achievements |
In spite of the "signaling endosome hypothesis", in which growth facor receptors elicite signals from endocytic vesicles upon stimulation, components and functions of such vesicles has been unclear.
In this study, we developed a easy and rapid method to isolate such vesicles and found colocalizations of most glycolytic enzymes to these vesicles. Furthermore, we found that interaction between such vesicles and mitochondria plays a crucial role for growth factor-evoked enhancement of cellular glycolysis, which is necessary for cellular survival.
These result significantly renew the current textbook model of glycolysis, in which glucose is transported through the plasma membrane and catabolized in the cytoplasm.
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| Free Research Field |
生化学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で明らかにした現象は、増殖因子受容体の活性化や糖代謝の亢進が知られているがんなどの疾病への関与が示唆され、新たな治療法の開発への展開が期待される。
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