2023 Fiscal Year Final Research Report
Study of the mechanism of induced graying by blocking blood flow and development of new methods for prevention and treatment of hair graying
| Project/Area Number |
20K06657
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 44020:Developmental biology-related
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 白髪モデルマウス / 血流遮断 / Dct / 色素幹細胞 / 老化 / 毛周期 / 毛包 / 薬剤開発 |
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| Outline of Final Research Achievements |
Gray hair was induced by pressing the dorsal skin of mice in growth phase of the hair cycle by putting with C-shaped neodymium magnets from both sides after pinched up and compressed for over 6 hours. Since pigment stem cells were also confirmed in the bulge area of gray hair follicles, it is thought that the cause is suppression of stem cells proliferation and differentiation. A mosaic pattern was formed in which gray hair or black hair was emerging from each hair follicle, but the mosaic pattern in the same skin region was maintained over three hair cycles.
When the skin of gray-haired mice was injected with pigment cell differentiation-promoting factors DBcAMP and Silibinin, the proportion of black hair increased by up to about 20% compared to the previous hair cycle. This gray-haired mouse which can be revived with appropriate treatment, is an ideal model for mimicking gray hair in the early stages of human aging and is useful for the development of gray hair-improving drugs.
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| Free Research Field |
皮膚科学
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| Academic Significance and Societal Importance of the Research Achievements |
毛色は色素細胞が毛周期の成長期に増殖・分化することで生じる。従来、老化やストレスによる白毛化は色素幹細胞の枯渇が原因と言われており、放射線連続照射による白毛誘導マウスモデルが知られている。一方、白毛化の初期段階では黒毛に回復することがあるが、この過程を模倣するモデル動物はなかった。我々はマウスの背部皮膚を磁石で挟んで圧迫すると白毛化が起こることを発見した。この白毛化マウスでは毛包色素幹細胞は残存しているものの、増殖や分化が抑制されており、色素細胞の分化促進因子を注射すると黒毛が増加した。すなわち、黒毛復活が可能な老化初期の白髪の良いモデルであり、白髪の機序解明や改善薬の開発などに有用である。
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