Experience-dependent switch in mechanisms for inhibitory neurons in cortical circuits processing.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K06869
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 46010:Neuroscience-general-related
• Research Institution: Niigata University
• Principal Investigator: Hou Xubin 新潟大学, 医歯学系, 助教 (00584765)
• Co-Investigator(Kenkyū-buntansha): 菱田 竜一 新潟大学, 脳研究所, 准教授 (90313551)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 抑制性ニューロン局所回路 / 超解像分子イメージング / 視覚弁別記憶課題 / 樹状突起 / 眼優位性可塑性 / 臨界期 / 深層学習行動解析 / Coactosin

Outline of Final Research Achievements

This study explores the developmental factors of inhibitory neurons, employing ultra-high-resolution imaging to elucidate their structural characteristics. A novel gene delivery technique targeting deep-brain cells has been developed, advancing our understanding of experience-dependent neural mechanisms. Analysis suggests that these developmental factors significantly influence local neural circuits, potentially enhancing visual discrimination. This research contributes to the broader field of neurobiology by linking morphological and functional attributes of neurons to cognitive processes.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

この研究は、特定のアクチン重合因子を通じて抑制性神経細胞の形態と生理機能的特性の決定における分子メカニズムの理解を深めた。新たな遺伝子操作技術と深層学習による行動解析は、視覚障害の治療方法の改善に応用可能であり、これにより臨床応用への道が開かれる可能性があります。