2022 Fiscal Year Final Research Report
Molecular mechanisms controlling social behaviors
Project/Area Number |
20K06872
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 46010:Neuroscience-general-related
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Research Institution | Osaka University |
Principal Investigator |
Usui Noriyoshi 大阪大学, 大学院医学系研究科, 准教授 (00784076)
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Co-Investigator(Kenkyū-buntansha) |
島田 昌一 大阪大学, 大学院医学系研究科, 教授 (20216063)
近藤 誠 大阪公立大学, 大学院医学研究科, 教授 (50633012)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 社会性 / 社会性行動 / ZBTB16 / 自閉スペクトラム症 / 統合失調症 / 大脳皮質 / 白質 / トランスクリプトーム |
Outline of Final Research Achievements |
In this study, to understand the molecular mechanisms controlling social behaviors, we investigated the functions of Zbtb16 in the brain. Zbtb16 knockout (KO) mice exhibited autism spectrum disorder-like and schizophrenia-like behaviors such as social impairment, repetitive behaviors, risk-taking behaviors, and cognitive impairment. We also found that the developmental abnormalities in the neocortex and oligodendrocytes were observed In Zbtb16 KO mice. Transcriptome analysis in the prefrontal cortex identified 533 genes involved in brain development and myelination. These genes were associated with transcriptomes in the postmortem brains from individuals with autism spectrum disorder or schizophrenia Together, we demonstrate that Zbtb16 is involved in the regulation of social behaviors through appropriate brain development and neural circuit formation.
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Free Research Field |
分子神経発達学
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Academic Significance and Societal Importance of the Research Achievements |
本研究ではこれまで脳におけるその機能が未解明であったZbtb16が社会性行動に関わることを見出した。社会性行動の障害に繋がる神経回路の同定とZbtb16によって制御される遺伝子群を網羅的に同定しており、自閉スペクトラム症や統合失調症など社会性が障害される疾患の病態メカニズムの理解や新たな治療標的に繋がることが期待される。
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