2022 Fiscal Year Final Research Report
Roles of Piezo1 channels expressed on smooth muscle for regulation of colonic motility
| Project/Area Number |
20K07093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47040:Pharmacology-related
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| Research Institution | Kyoto Sangyo University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Piezo1チャネル / 機械刺激感受性イオンチャネル / 大腸運動 / 平滑筋細胞 / Ca2+ |
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| Outline of Final Research Achievements |
The contractility of smooth muscle changes in response to mechanical stretching caused by luminal contents in the gastrointestinal tract, mediated by mechanosensitive ion channels. In this study, we aimed to elucidate the roles of Piezo1 channels, which have been identified as a new class of mechanosensitive nonselective cationic channels, in regulation of colonic motility. Our results suggest that Piezo1 channels expressed on smooth muscle cells contribute to the excitatory regulation of colonic smooth muscle contractions.
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| Free Research Field |
薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
大腸平滑筋の収縮調節におけるPiezo1チャネルの役割を明らかにした本研究の成果は，未解明な点が多く残されている腸管運動制御メカニズムの全容を解明するうえで，重要な情報となる。Piezo1チャネルの機能不全は，過敏性腸症候群などの消化管運動障害につながることが予想される。それ故，本研究の成果は，消化管運動障害におけるPiezo1チャネルの関与やPiezo1チャネルをターゲットとした治療薬の開発に向けた将来的な研究の実施に向けても，基盤的な情報になると考えられる。
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