2022 Fiscal Year Final Research Report
Elucidation of a novel regulatory axis of glycolysis in cancer stem cells based on cancer genomics database analysis
Project/Area Number |
20K07207
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 47060:Clinical pharmacy-related
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Research Institution | Tokyo University of Science |
Principal Investigator |
Akimoto Kazunori 東京理科大学, 薬学部生命創薬科学科, 教授 (70285104)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 癌の層別化 / 公共の癌ゲノムデータ / 癌幹細胞 / 解糖系 / データサイエンス手法 |
Outline of Final Research Achievements |
It is revealed the details of a new glycolytic regulatory mechanism. Specifically, direct phosphorylation of transcription factor X by PKCλ is involved in the intracellular stabilization of protein X by avoiding proteasomal degradation, and that this mechanism is related to the glycolytic and pentose phosphate pathways and was one of the major regulatory mechanisms of their pathways in ALDH1-positive breast cancer stem cells. In addition, it was also revealed that the novel mechanism is involved in the asymmetric cell division of ALDH1-positive cancer stem cells, and a new stratification of breast cancer has also progressed. The series of the results will contribute to the detailed understanding on the glycolytic and drug metabolisms of cancer stem cells, as well as the development of new biomarkers and molecular targeted drugs for cancer.
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Free Research Field |
分子腫瘍学
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Academic Significance and Societal Importance of the Research Achievements |
公共の癌ゲノムデータベース解析を起点にしてデータサイエンス手法(主に統計学的手法とバイオインフォマティクス)と癌生物学的手法を融合するかたちで研究を進めた。一連の研究成果は、乳癌の新たな層別化とともに、癌幹細胞の糖代謝機構や薬物代謝機構の研究の進展に寄与する。本研究で用いたアプローチはグローバルで蓄積しつつある公共のビッグデータや医療データの解析研究に新たな切り口を提供するとともに、癌の新たなバイオマーカーや分子標的の同定に役立ち、癌治療における新たな診断法や治療薬の開発に貢献する。
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