2023 Fiscal Year Final Research Report
Study on the mechanisms of head formation using in utero live imaging: association and cooperation of cells intra- and extra-brain primordium.
Project/Area Number |
20K07224
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 48010:Anatomy-related
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Research Institution | Fujita Health University |
Principal Investigator |
Saito Kanako 藤田医科大学, 医学部, 講師 (50746906)
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Project Period (FY) |
2020-04-01 – 2024-03-31
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Keywords | 神経幹細胞 / ニューロン / マウス頭部発生 / ライブ観察 |
Outline of Final Research Achievements |
This study, through the imaging of the embryonic mouse head, the view was extended to the whole head, not just the brain primordium, with an awareness of the spatiotemporal relationships between different types of cell groups. This allowed us to deepen our understanding of the various organogenesis of the head by observing at the single-cell level, while maintaining the relationships within the tissue. We also examined the morphological changes in the brain and head tissue from a mechanical perspective, focusing on the epidermis and connective tissue surrounding the brain, which is one of the factors that contribute to changes in tissue formation during early development, both intrinsic factors in cells and extrinsic factors received from neighbouring cells and tissues.
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Free Research Field |
神経発生
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Academic Significance and Societal Importance of the Research Achievements |
オルガノイド作成技術は日進月歩で、消化器系なら、複数の異なる器官を同時に、それらの間にあるべきつながりを持たせて、生じさせるにまで至っている。しかし、本来より幹細胞の持つ「自己組織化」と称される自己複製能や多分可能による工程も多い。本研究は、将来、異種細胞の会合・協働を人為的にコントロール出来る為に有用になると思われる。また、これらの成果は、頭部のさまざまな器官形成のしくみについて、新しい理解をもたらすと予想される。
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