2022 Fiscal Year Final Research Report
Histologic exploration of myocardial connection at the atrioventricular junction for the possible unknown arrhythmogenicity.
| Project/Area Number |
20K07232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 48010:Anatomy-related
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
原口 亮 兵庫県立大学, 応用情報科学研究科, 准教授 (00393215)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 心臓形態 / 不整脈 / 刺激伝導系 / 心臓性突然死 / 房室弁輪 / 病理組織形態 |
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| Outline of Final Research Achievements |
Histopathologic analysis around the atrioventricular annuli in adult human hearts without histories of major arrhythmias was performed to explore unknown possible arrhythmogenic substrates. Although suspicious myocardial bundles that could be a cause of the cardiac arrhythmias were not obvious in the bilateral atrioventricular annuli, the distance between the atrial and ventricular myocardium at the right atrioventricular annulus was shorter and closer than the left atrioventricular annulus. This difference of myocardial contiguity at the left and right atrioventricular annulus is due to the difference of the myocardial trabeculation just beneath the atrioventricular annulus, and the specific structures such as "specialized cells" located at the attachment of the right atrioventricular annulus.
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| Free Research Field |
Pathology
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| Academic Significance and Societal Importance of the Research Achievements |
房室弁輪部分には検索した範囲では房室伝導系以外の心房-心室を電気的に連絡しうる心筋の連続性は見出せなかったが、左右の房室弁輪の構造の違いにより特に右側房室弁輪では心房-心室筋の近接した構造がみられ、それは弁輪周囲の心筋配列の特徴によるものでった。また、年齢的な変化も明らかになり、同部位に発生する不整脈の形態学的な基盤として重要な情報であると思われた。これらの明らかになった解剖学的形態は、今後同部位から発生する不整脈の機序の解明や治療法の開発の一助になる可能性も考えられた。
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