Functional abnormalities of primary cilia in pancreatic cancer and their linkage to clinicopathological characteristics

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K07371
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Mie University
• Principal Investigator: UCHIDA KATSUNORI 三重大学, 医学部附属病院, 講師 (60362349)
• Co-Investigator(Kenkyū-buntansha): 広川 佳史 三重大学, 医学系研究科, 准教授 (30322738) ; 岸和田 昌之 三重大学, 医学部附属病院, 准教授 (40501961) ; 石井 健一朗 三重大学, 医学系研究科, リサーチアソシエイト (90397513)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 一次線毛 / 膵癌

Outline of Final Research Achievements

The presence or absence of primary cilia was confirmed in pancreatic cancer cases that had undergone preoperative treatment and pancreatic cancer cases that had not undergone preoperative treatment. On the other hand, in the group with preoperative treatment, primary cilia were found in cancer cells with degeneration that may have been caused by the treatment, but not in cancer cells without degeneration. In the case of the cancer cell lines, we confirmed the appearance of primary cilia due to treatment, similar to the results obtained from clinical specimens. These results indicate that the appearance of primary cilia in pancreatic cancer may be an indicator of the efficacy of preoperative treatment.
However, the function of the USP8/CRL3/Tricho/AurA pathway, a primary cilia regulator, remains to be elucidated.

Free Research Field

病理学

Academic Significance and Societal Importance of the Research Achievements

治療が行われ、かつ効果があるとされる癌細胞には一次線毛が出現していることが明らかとなった。膵癌に対する術前治療効果の客観的指標は現在まで確立されていないが、今回の研究により、一次線毛が術前治療の効果を推測する客観的指標となりうる可能性が示された。