2022 Fiscal Year Final Research Report
Langerhans cell histiocytosis-Analysis of new biomarkers using NGS (small RNA)
| Project/Area Number |
20K07393
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49020:Human pathology-related
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| Research Institution | Kochi University |
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Principal Investigator |
Murakami Ichiro 高知大学, 教育研究部医療学系連携医学部門, 教授 (80548701)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Histiocytosis / RNA-Seq / mRNA / ncRNA |
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| Outline of Final Research Achievements |
The cause of Langerhans cell histiocytosis (LCH) is uncertain, whether it is neoplastic or reactive disease (KAKENHI 20K07393). Various involvements such as viral infections, congenital anomalies, etc. have been investigated (Hum Pathol, 2014).
We obtained data suggesting that LCH may be a reactive disease with neoplastic characteristics, and analyzed LCH patient sera by mass spectrometry, followed by RNA-Seq using LCH patient sera.
LCH is now recognized as an inflammatory myeloid neoplasm.
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| Free Research Field |
Pathology
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| Academic Significance and Societal Importance of the Research Achievements |
Based on these data, it is suggested that therapeutic strategies should target not only neoplastic disease but also reactive disease.
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