2022 Fiscal Year Final Research Report
Effects of synthetic and natural compounds on carcinogenesis and cancer growth in the activation and/or regulation of immune systems in cancer microenvironments
| Project/Area Number |
20K07804
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Osaka Medical and Pharmaceutical University (2021-2022)
Ehime University (2020) |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 癌 / 伝統薬物成分 / 薬理学 / 生理活性 / 免疫機能 |
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| Outline of Final Research Achievements |
Traditional drug compound Resveratrol-related four stilbenes (2,3-, 3,4-, 4,4'-Dihydroxystilbene and Piceatannol(3,5,3',4'-Tetrahydroxystilbene), Tetra- and Penta-hydroxyflavanoneisolated from Scutellarae Radix, Acetannin isolated from Acer speices, and Geniposide isolated from Gardeniae Fructus were inhibited the colon tumor growth by inhibiting colonic IL-1beta, PD-1 via down-regulated expression of COX-2 and TOX/TOX2 (CD8 T cell exhaustion) through the inhibition of Phospho-STAT3 expression in azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated C57BL/6J mice.
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| Free Research Field |
薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
大腸癌に罹患率が増加している状況で、癌死亡率の上位を占めている。潰瘍性大腸炎やクーロン病は難病指定され、大腸癌発生のリスクファクターである。「サトウカエデ」中のAcertanninのデキストラン硫酸Na誘発大腸炎を結腸中IL-23およびTNF-αの上昇の阻害を介して大腸炎を抑制した。Azoxymethane（AOM)およびDextran Sulfate Sodium （DSS）誘発大腸癌は、Hydroxystilbene類、Hydroxyflavanone、GeniposideやAcertanninの経口投与よって抑制された。以上の成果は、新たな大腸癌の治療薬候補となる可能性がある。
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