2022 Fiscal Year Final Research Report

Application of glycoproteins involved in pancreatic cancer cell invasion as diagnostic markers for pancreatic cancer

Research Project

PDF

Project/Area Number	20K07806
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52010:General internal medicine-related
Research Institution	Kochi University
Principal Investigator	Yoshioka Reiko 高知大学, 教育研究部医療学系臨床医学部門, 助教 (60868975)
Co-Investigator(Kenkyū-buntansha)	谷内恵介高知大学, 教育研究部医療学系臨床医学部門, 准教授 (50626869)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	膵癌 / 診断マーカー
Outline of Final Research Achievements	The principal investigator identified a transmembrane protein (glycoprotein A) and a secreted glycoprotein B, which are involved in cell invasion and metastasis through local translation in the lamellipodia of pancreatic cancer cells. In a prospective clinical study, glycoprotein A and B concentrations in serum from patients with pancreatic cancer, esophageal cancer, gastric cancer, hepatic cancer, bile duct/gallbladder cancer, and colon cancer were measured by ELISA. Glycoproteins A and B were significantly elevated in pancreatic cancer serum. As a result of measuring the concentration of glycoproteins A and B in serum of human pancreatic cancer organoid-implanted mice by ELISA method, glycoproteins A and B are higher than CA19-9, a pancreatic cancer tumor marker, from the small stage of human pancreatic cancer tissue.
Free Research Field	消化器内科　膵癌
Academic Significance and Societal Importance of the Research Achievements	本研究を推進することにより、画像診断により進行癌として見つかることの多い膵癌に対する新たな診断方法の確立が期待できる。採血によって検査が可能であり、将来は集団検診への利用が可能であると考えている。感度・特異度の高い診断マーカーにより、予後の最も悪い癌である膵癌を高い精度でかつ集団検診でも利用できる効率的な検診方法の開発は急務であり、本研究の成果はこれらのことを実現できる可能性がある。診断の難しい膵癌を正確に簡便な方法で診断することは、膵癌の新しい治療体系を確立できる可能性もあり、日本の医療水準を高めることに貢献できると考えている。