Elucidation of hypoxia-responsive genes that control recurrence after hepatic artery embolization and development of siRNA-loaded embolization preparations

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K08010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Hyogo Medical University
• Principal Investigator: Takaki Haruyuki 兵庫医科大学, 医学部, 准教授 (30378377)
• Co-Investigator(Kenkyū-buntansha): 平田 豊 兵庫医科大学, 医学部, 講師 (10441247) ; 山門 亨一郎 兵庫医科大学, 医学部, 教授 (20263022) ; 児玉 大志 兵庫医科大学, 医学部, 助教 (20422834) ; 鈴木 亮佑 神戸学院大学, 薬学部, 講師 (80611540)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 肝癌 / 肝動脈塞栓術 / 低酸素誘導因子 / マイクロ粒子 / siRNA

Outline of Final Research Achievements

In this study, using a biodegradable polymer, we attempted to develop a new vascular embolization material that can be applied to prevent recurrence after hepatic artery embolization. By adjusting the ratio of the polymer solvent and the stabilizing water, the flow rate during preparation, etc., it became possible to freely adjust the particle size. Furthermore, it led to the development of new vascular embolization substances that can inhibit hypoxia-inducible factors involved in liver cancer recurrence.

Free Research Field

Interventional Radiology (IVR)

Academic Significance and Societal Importance of the Research Achievements

肝動脈塞栓術後の再発抑制に応用可能な、新しい血管塞栓物質の開発基盤を確立した。更に、肝癌再発に関与する低酸素誘導因子を標的とする新しい塞栓物質のプロトタイプも作成することができた。今後、臨床への応用が期待される。