2023 Fiscal Year Final Research Report
Study on development and application of three-dimensional radiochromic gel dosimeter using iodine complex
| Project/Area Number |
20K08039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Hiroshima International University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
五東 弘昭 横浜国立大学, 大学院工学研究院, 准教授 (80635235)
小林 毅範 帝京大学, 医療技術学部, 教授 (10459365)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | ３次元ゲル線量計 / ラジオクロミックゲル / 医学物理学 / 放射線治療 / 治療計画 / 光学CT装置 / 放射線化学 / 化学線量計 |
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| Outline of Final Research Achievements |
As a tool for directly evaluating three-dimensional dose distribution in radiotherapy, we developed a new radiochromic gel dosimeter that utilizes the red color produced by the complex of iodine and polyvinyl alcohol formed in a gel solution by radiation. We optimized the composition, improved the properties using various additives, and evaluated the basic properties. As a result, significant improvements have been made in terms of temporal, spatial, and thermal stability, as well as dose response (sensitivity). At the same time, we worked on its clinical application and established a method for using it as a position detector for evaluating deep dose distribution and ensuring accuracy for X-rays and electron beams from medical accelerators. Furthermore, we created an optical CT device that is essential for three-dimensional dose distribution evaluation, and compared it with the treatment plan, demonstrating its usefulness.
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| Free Research Field |
放射線化学
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| Academic Significance and Societal Importance of the Research Achievements |
三次元ゲル線量計，特にラジオクロミックゲル（RG）線量計の開発と臨床応用は，これまで欧米の研究が先行していたが，我々の開発した新規なRG線量計は既存のRG線量計とは異なる発色機構を用いており，国産のRG線量計である．我々のRG線量計では既存のRG線量計のいくつかの欠点が改善されており，再利用可能である点も画期的である．また，自作した汎用型光学CT装置と併せたシステムを構築し，RG線量計を実臨床へ応用する手法をいくつか確立した．これらの成果は今後の放射線治療における三次元線量分布評価法として臨床への普及にも大きく貢献できると考えている．
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