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2022 Fiscal Year Final Research Report

High signal intensity on diffusion weighted images reflects acute phase of deep vein thrombus

Research Project

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Project/Area Number 20K08085
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionUniversity of Miyazaki

Principal Investigator

Kuroiwa Yasuyoshi  宮崎大学, 医学部, 研究員 (20747232)

Co-Investigator(Kenkyū-buntansha) 山下 篤  宮崎大学, 医学部, 教授 (90372797)
Project Period (FY) 2020-04-01 – 2023-03-31
Keywords深部静脈血栓症 / 拡散強調画像 / 赤血球 / 核磁気共鳴画像 / 病理学
Outline of Final Research Achievements

Venous thromboembolism (VTE) is a severe condition where thrombi in the lower extremities or pelvic region obstruct the pulmonary artery. It often presents without symptoms, and the risk of bleeding associated with anticoagulant therapy has become a concern. Recent studies have reported a method for visualizing thrombi by combining diffusion-weighted imaging (DWI) and T1-weighted imaging in MRI. In this study, clinical images, animal models, and blood MRI were employed to elucidate the relationship between DWI features and diffusion coefficients. DWI clearly depicted thrombi and captured changes in signal intensity and apparent diffusion coefficient (ADC) values over time. The presence of erythrocyte components suggesting diffusion restriction within the thrombus was also indicated. Consequently, DWI in MRI holds promise as a qualitative imaging diagnostic tool for the diagnosis and treatment of deep vein thrombosis.

Free Research Field

放射線科学関連

Academic Significance and Societal Importance of the Research Achievements

新たな研究では、静脈血栓塞栓症の診断と治療に役立つ画像診断法が開発されました。この病気は、下肢や骨盤内の血栓が肺動脈を詰まらせる重篤な状態で、多くの患者は症状がないままです。しかし、抗凝固薬の使用による出血リスクが懸念されています。最新の研究では、MRIの画像技術を使用して、血栓を視覚化する方法が報告されました。臨床画像やモデル動物、血液を用いて、画像の特徴と血栓の性質の関係を明らかにしました。これにより、血栓の正確な描写や時間の経過に伴う変化を捉えることができます。この研究結果により、MRIの画像診断法が静脈血栓塞栓症の早期発見や適切な治療に貢献することが期待されます。

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Published: 2024-01-30  

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