Elucidation of the molecular mechanisms underlying the coupling between DNA repair and cell cycle regulation for the optimization of radiotherapy

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K08127
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: The University of Tokyo
• Principal Investigator: Hosoya Noriko 東京大学, 大学院医学系研究科(医学部), 准教授 (00396748)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: DNA修復 / 細胞周期

Outline of Final Research Achievements

In order to clarify the link between DNA repair and cell cycle regulation, we investigated the roles of the proteins involved in homologous recombination in cell cycle progression in G0/G1 phase. We found that RAD51 and some other homologous recombination-related proteins promote cell cycle progression in G0/G1 phase, which cannot be explained by their roles in DNA double-strand break repair in the cell nucleus acting in the S and G2 phases.

Free Research Field

放射線基礎医学、放射線生物学、腫瘍生物学

Academic Significance and Societal Importance of the Research Achievements

相同組換え関連分子が、G0/G1期の細胞周期の進行を制御していることが分かった。このことから、相同組換え関連分子は、S期後半からG2期にかけての細胞核におけるDNAの二本鎖切断に対する修復以外の機能も有していることが示唆され、相同組換え分子の新たな役割を探索するきっかけになった点で意義は大きい。