The new therapy for preterm lung injury using hydrogen gas

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K08159
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Kagawa University
• Principal Investigator: Kondo Sonoko 香川大学, 医学部, 助教 (70437680)
• Co-Investigator(Kenkyū-buntansha): 荻原 享 大阪医科薬科大学, 医学部, 功労教授 (00211128) ; 安田 真之 香川大学, 医学部附属病院, 准教授 (00380155) ; 中村 信嗣 香川大学, 医学部附属病院, 助教 (30437686) ; 日下 隆 香川大学, 医学部, 教授 (50274288) ; 山岡 繁夫 大阪医科薬科大学, 医学部, 助教 (90434779)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 水素ガス / 低酸素虚血 / 新生仔豚 / 虚血再灌流肺障害

Outline of Final Research Achievements

We investigated the effects of hydrogen gas on the heart and lungs following ischemia-reperfusion after hypoxia-ischemia in a neonatal piglet. Ten neonatal piglets within 24 h of birth were subjected to a hypoxic-ischemic (HI) insult, and then divided into two groups: insult + no treatment group (HI, n=5), and insult + hydrogen gas inhalation group (HI-H2, 2.1-2.7% hydrogen gas for 6 h, n=5). RESULTS: The right cardiac output of the HI-H2 group was significantly higher than that of the HI group at 5 h after insult, and the pulmonary artery acceleration time change tended to be longer in the HI-H2 group than in the HI group. The HI-H2 group had significantly more pulmonary neutrophils than the HI group, but there was a significant positive correlation between 5h right CO and pulmonary neutrophils, and the HI-H2 group tended to have fewer pulmonary neutrophils per right cardiac output than the HI group.

Free Research Field

新生児

Academic Significance and Societal Importance of the Research Achievements

本研究結果から、低酸素虚血後の心臓や肺において、水素ガスは、右心機能を改善し、さらに肺における好中球も減少させる効果があることが明らかになったことにより、臨床におけるHIE児でも、脳保護効果だけではなく、心機能改善効果や肺における抗炎症効果も期待できることから、脳・心臓・肺における保護効果をもつ水素ガスは、HIE児の予後改善に寄与できる可能性が高い。