Efficacy of oral probiotics at birth for neonates born by cesarean section.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K08235
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Juntendo University
• Principal Investigator: HISATA KEN 順天堂大学, 医学部, 准教授 (10420853)
• Co-Investigator(Kenkyū-buntansha): 大日方 薫 順天堂大学, 医学部, 客員教授 (10204281) ; 堀 賢 順天堂大学, 大学院医学研究科, 教授 (80348937)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 新生児 / プロバイオティクス / 帝王切開

Outline of Final Research Achievements

A study was designed to induce normal intestinal microflora by administering bifidobacteria to newborns born by cesarean section. A randomized, double-blind, placebo-controlled, parallel study was conducted at a single obstetric center. Patients were randomly assigned at 35-37 weeks gestation using a stratified substitution block method, were given the assigned foods internally for the first 3 days of life, and stool and urine samples were collected at obstetric discharge, at 1 month of age, and at 3 months of age.
Assigned foods were administered to 40 newborns, and samples were collected at 1 month of age and 3 months. Currently, gut microbiota analysis by 16SrRNA sequencing has been completed and case fixation is underway. A statistical analysis will be performed between the bifidobacteria and placebo groups.

Free Research Field

新生児

Academic Significance and Societal Importance of the Research Achievements

近年、様々な疾病の発症もしくは増悪に腸内細菌叢が関連することが分かってきた。直接的な因果関係について十分に解明された段階には至っていないが、帝王切開での出生、そして、帝王切開に伴う腸内細菌叢の変化もまた、将来的な疾病の発症リスクになり得る可能性が報告されている。その一方で、帝王切開は母子の安全を考慮した分娩方法であり、世界的には増加傾向にある。従って、帝王切開で出生した新生児の腸内細菌叢を、経腟分娩に類似した正常な腸内細菌叢へと誘導することができれば、将来的な疾病の発症リスクの軽減につながる可能性がある。本研究の解析結果に統計学的有意差が出ることは、予防医学の観点から意義の高い研究となる。