2023 Fiscal Year Final Research Report

Association of water-retaining mucins with metabolites derived from the intestinal microbiota

Research Project

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Project/Area Number	20K08294
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 53010:Gastroenterology-related
Research Institution	Kitasato University
Principal Investigator	Ichikawa Takafumi 北里大学, 医療衛生学部, 教授 (30245378)
Co-Investigator(Kenkyū-buntansha)	川島麗北里大学, 医療衛生学部, 准教授 (70392389) 河村由紀国立研究開発法人国立国際医療研究センター, その他部局等, 消化器病態生理研究室長 (10392391)
Project Period (FY)	2020-04-01 – 2024-03-31
Keywords	ムチン / 腸内細菌 / NSAIDs / 粘膜防御 / H2ブロッカー
Outline of Final Research Achievements	To elucidate the relationship between mucin, which has a water-supplying function, and intestinal bacteria, a model of NSAIDs administration that reduces mucin secretion and a histamine H2 receptor antagonist H2RA that improves intestinal inflammation were tested, Clostridiales decreased, but both were restored by concomitant use of H2RA. Fecal levels of acetic acid, propionic acid, and n-butyric acid increased with IDM administration and decreased with concurrent H2RA; fecal mucin and IgA levels decreased in the IDM group and recovered in the IDM+H2RA group. Thus, it is suggested that mucin, a mucosal defense that has the ability to retain water, may regulate the intestinal microbiota.
Free Research Field	消化器病学
Academic Significance and Societal Importance of the Research Achievements	これまで臨床で汎用されてきた止瀉薬（下痢止め）は、管腔内の水分吸収作用を機序とするため、即効性はあるが根本治療にはつながらない。日常的に下痢となる過敏性腸症候群（IBS）のような慢性下痢症に対してこの薬剤は不適であり、精神的ストレスを軽減するのが根本解決といえども現実的ではない。そこで即効性がない反面、一度産生されると一定期間の産生維持と腸内環境改善が期待できるムチンという局面から腸内環境に合わせた水分調節を図る効果的な薬効アプローチをここに提言する。