The association of PCSK7 with coronary calcification

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K08415
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Kataoka Yu 国立研究開発法人国立循環器病研究センター, 病院, 医長 (70463271)
• Co-Investigator(Kenkyū-buntansha): 古橋 眞人 札幌医科大学, 医学部, 教授 (20563852) ; 小倉 正恒 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (30532486)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: PCSK7 / 石灰化 / 冠動脈

Outline of Final Research Achievements

The association of OCT-derived calcification with PCSK7 levels was analyzed in 58 patients with CAD. An increase in PCSK7 level was associated with a greater calcification (r=0.56, p=0.04). We investigated whether PCSk7 level could predict future cardiovascular events in 280 patients. There was a trend toward an increased risk of cardiovascular events in association with elevated levels of PCSK7. In 282 healthy subjects, we investigated factors associated with PCSK7. Liver function, obesity and triglyceride were associated with PCSK7 levels.

Free Research Field

動脈硬化症

Academic Significance and Societal Importance of the Research Achievements

PCSK7は石灰化形成や将来の心血管イベント発生に関与する可能性が示唆された。さらなる大多数の症例で検証を要する。