Energy metabolism of idiopathic pulmonary arterial hypertension

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K08424
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Okayama University
• Principal Investigator: Akagi Satoshi 岡山大学, 医歯薬学域, 助教 (60601127)
• Co-Investigator(Kenkyū-buntansha): 中村 一文 岡山大学, 医歯薬学域, 准教授 (10335630) ; 吉田 賢司 岡山大学, 医歯薬学域, 講師 (70532761) ; 伊藤 浩 岡山大学, 医歯薬学域, 教授 (90446047)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 肺動脈性肺高血圧症 / 肺動脈平滑筋細胞 / エネルギー代謝 / 糖代謝 / ミトコンドリア呼吸

Outline of Final Research Achievements

Pulmonary artery smooth muscle cells (PASMCs) of pulmonary arterial hypertension (PAH) have similar metabolic characteristics of cancer cells. We investigated metabolic state of PAH-PASMCs under normoxia and hypoxia. Glycolytic switch was occurred under normoxia and mitochondrial respiration was preserved under hypoxia in PAH-PASMCs, which resulted in increase of ATP production in PAH-PASMCs under hypoxia. These characteristics of energy metabolism in PAH-PASMCs under normoxia and hypoxia might be involved in the pathogenesis of PAH.

Free Research Field

医学　循環器内科　肺高血圧症

Academic Significance and Societal Importance of the Research Achievements

PAHの肺動脈平滑筋細胞において、今回明らかになったエネルギー代謝の特性はこれまで知られていない。そのためこの特性に介入できる薬剤を開発できれば、新たなPAHの治療薬として期待できる。