2022 Fiscal Year Final Research Report
Elucidation of the Mechanism of Cancer Progression in the Pathogenesis of Heart Failure - Therapeutic Intervention in the Brain-Mind-Tumor Interaction
| Project/Area Number |
20K08493
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 53020:Cardiology-related
|
|---|
| Research Institution | Fukushima Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | 腫瘍循環器 / 乳がん / 心不全 / 神経栄養因子 |
|---|
| Outline of Final Research Achievements |
We analyzed the mechanisms between heart failure and cancer progression using a breast cancer mouse model with myocardial infarction. Mice implanted with 4T1 cells 2 weeks after myocardial infarction showed increased amounts of breast cancer tissue compared to sham mice. NGF levels in the blood of infarcted mice were increased, and NGF stimulation on 4T1 cells resulted in an increase in tumor cells. When TRKA expression was reduced using siRNA, increase of 4T1 cells was suppressed. Thus, it was concluded that NGF increased by myocardial infarction promotes breast cancer progression.
|
| Free Research Field |
腫瘍循環器
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究は心筋梗塞により増加したNGFががん進行促進をもたらすことを示した初めての研究となる。心不全患者にがん発生が多いことは疫学研究から明らかとなっているが、その原因は不明であった。本研究はそのメカニズムの一つを示した研究である。また、NGFの受容体であるTRKAに対するTRKA阻害薬ががん細胞増殖抑制に有用であったことから、同阻害薬の使用が、がんに対する新たな治療アプローチにつながる可能性があり、今後の発展が期待される。
|
