Elucidation of fibrosis in hypersensitivity pneumonitis: Antigen-presenting cells and gdT cells

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K08515
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Miyazaki Yasunari 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30396999)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 過敏性肺炎 / 樹状細胞 / γδT細胞

Outline of Final Research Achievements

Hypersensitivity pneumonitis develops due to an allergic reaction caused by a chain of antigen-presenting cells and immune cells. In this study, we elucidated the roles of dendritic cells and γδT cells in fibrosis, which have not been elucidated in the chain process of allergic reactions. IL-17A-producing γδ T cells were found to increase in bird-associated hypersensitivity pneumonitis, but not in the farmer's lung model. ConventionalDC2 was predominantly increased in the anti-bird-associated hypersensitivity pneumonitis model, suggesting that it is related to immune linkage to Th17.

Free Research Field

びまん性肺疾患

Academic Significance and Societal Importance of the Research Achievements

過敏性肺炎は特定の抗原に対する免疫・アレルギー反応で発症する間質性肺炎である。このうち慢性過敏性肺炎は潜在性に肺が線維化する。慢性・線維化するタイプはの5年生存率は30〜40%と極めて予後不良である。本研究成果により特発性肺線維症にも共通する肺線維化のメカニズムが明らかになり、線維化をきたす間質性肺炎の治療の一助になると考える。