2022 Fiscal Year Final Research Report
The role of epidermal and vaginal epithelial resident memory T cells on HIV infection
| Project/Area Number |
20K08687
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | University of Yamanashi |
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Principal Investigator |
Ogawa Youichi 山梨大学, 大学院総合研究部, 講師 (20377542)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | HIV / resident memory T細胞 / 皮膚 / 膣 / 潜伏感染 |
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| Outline of Final Research Achievements |
Resident memory T (TRM) cells are present in peripheral tissue including epidermis and vaginal epithelium. Since CD4+ T cells are the target of HIV infection, HIV infectivity in CD4+ TRM was examined. Both the fraction of CD103+ and CD103- equivalently infected to HIV. However, CD103+ fraction subsequently underwent apoptosis, but not CD103- fraction. This is because HIV-infected CD103-CD4+ T cells became latent. Moreover, OX40 signal may mediate this latent HIV infection.
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| Free Research Field |
皮膚免疫
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| Academic Significance and Societal Importance of the Research Achievements |
膣に暴露されたHIVは膣上皮に存在する抗原提示細胞であるランゲルハンス細胞 (LC)に感染し, HIV感染LCが所属リンパ節に遊走しCD4+T細胞にHIVを受け渡すと考えられてきた. しかし、膣上皮にCD4+TRMが存在することが明らかとなり, HIVの初期感染標的となる可能性が考えられた. CD103-分画のCD4+TRMはHIV感染後, HIV潜伏感染細胞となることが明らかとなった. このことはHIV感染予防には, LCおよびCD4+TRMでのHIVの感染を阻害することが重要であることを示唆する.
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