Examining the epidermal resident memory T cell of psoriasis model mouse

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K08696
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Teikyo University
• Principal Investigator: Tada Yayoi 帝京大学, 医学部, 主任教授 (00334409)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 乾癬

Outline of Final Research Achievements

Recently, it has been reported that resident memory T cells (TRMs), which are characteristic of psoriasis, remain in the epidermis of lesions with the ability to produce IL-17A even in remission after treatment, and may be involved in the relapse of skin rash. In this study, we confirmed the presence of TRM (CD8+CD69+CD103+) with the same characteristics in the epidermis of psoriasis IMQ model mice. We confirmed that this TRM could be activated by epidermal cells. These cells were able to produce cytokines when stimulated. The results of this study suggest that TRMs may be involved in psoriasis exacerbation by stimulating T cells to produce cytokines.

Free Research Field

皮膚

Academic Significance and Societal Importance of the Research Achievements

乾癬は慢性の炎症性皮膚疾患であるが、同じ場所に皮疹が再燃を繰り返すことが分かっており、何らかの皮疹の記憶が皮膚に残っているとされている。乾癬の表皮内に　resident memory T cell (TRM)があることがわかり、これが乾癬を治療後も表皮内に残る。我々はこのヒトのTRMと同じ性質をもつ細胞をマウスのイミキモド乾癬モデルマウス皮膚にもあることを同定した。この細胞は表皮細胞との共培養ややT細胞を活性化する刺激によりサイトカイン産生をすることから、乾癬の病態に関連すると考える。